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Cryo-Electron Microscopy Achieves Unprecedented Resolution Using New Computational Methods

Cryo-electron microscopy (cryo-EM)—which enables the visualization of viruses, proteins, and other biological structures at the molecular level—is a critical tool used to advance biochemical knowledge. Now Lawrence Berkeley National Laboratory (Berkeley Lab) researchers have extended cryo-EM’s impact further by developing a new computational algorithm that was instrumental in constructing a 3-D atomic-scale model of bacteriophage

New Machine Learning Technique Provides Translational Results

A team of scientists at Berkeley Lab has developed an unsupervised multi-scale machine learning technique that can automatically and specifically capture biomedical events or concepts directly from raw data.

What a Genome-Wide Screening Can Reveal about Cancer Survival

Berkeley Lab researchers have developed a 12-gene score tied to the odds of relapse-free breast cancer survival. The scoring system is based upon an analysis of large genomic datasets and patient data, and it could eventually be developed for clinical use.

Thirdhand Smoke Affects Weight, Blood Cell Development in Mice

Berkeley Lab researchers found that the sticky residue left behind by tobacco smoke led to changes in weight and blood cell count in mice. These latest findings add to a growing body of evidence that thirdhand smoke exposure may be harmful.

Berkeley Lab Gets $4.6M in Functional Genomics Catalog Project

Berkeley Lab is set to receive $4.6 million over four years as part of an ongoing, federally funded project to create a comprehensive catalog for fundamental genomics research. This latest expansion of the Encyclopedia of DNA Elements (ENCODE) project, or ENCODE 4, is funded by the National Human Genome Research Institute.

Berkeley Lab Breaks Ground on Integrative Genomics Building

Extending the roots of team science at its birthplace, Berkeley Lab will soon bring together researchers from the DOE Joint Genome Institute with those from the Systems Biology Knowledgebase (KBase) under one roof. The groundbreaking for the Integrative Genomics Building (IGB) today celebrates the future colocation of two partnering scientific user community resources and launches construction of the first building in the long-term vision for a consolidated biosciences presence on Berkeley Lab’s main site.

New Graphene-Based System Could Help Us ‘See’ Electrical Signaling in Heart and Nerve Cells

Scientists have enlisted the exotic properties of graphene to function like the film of an incredibly sensitive camera system in visually mapping tiny electric fields. They hope to enlist the new method to image electrical signaling networks in our hearts and brains.

3-D Imaging Technique Maps Migration of DNA-carrying Material at the Center of Cells

Scientists have produced detailed 3-D visualizations that show an unexpected connectivity in the genetic material at the center of cells, providing a new understanding of a cell’s evolving architecture.

Gatekeeping Proteins to Aberrant RNA: You Shall Not Pass

Berkeley Lab researchers found that aberrant strands of genetic code have telltale signs that enable gateway proteins to recognize and block them from exiting the nucleus. Their findings shed light on a complex system of cell regulation that acts as a form of quality control for the transport of genetic information. A more complete picture of how genetic information gets expressed in cells is important in disease research.

Navigating an Ocean of Biological Data in the Modern Era

Scientists and software engineers at the U.S. Department of Energy (DOE)’s Joint BioEnergy Institute (JBEI) have developed a new -omics visualization tool, Arrowland, which combines different realms of functional genomics data in a single intuitive interface. The aim of this system is to provide scientists an easier way to navigate the ever-growing amounts of biological